Overview of Nadifloxacin User Reviews

This section contains all of the individual user reviews and antibiotic susceptibilty rankings for Nadifloxacin (Nadixa, Nadiflox).

If you have used Nadifloxacin as a treatment for acne vulgaris, please share your experience and opinions.

Type of Treatment: Rx Medication – Antibiotic (Topical) - Quinolone Family

How It Works: Nadifloxacin is an antibiotic. Antibiotics can improve acne symptoms by limiting the growth of bacteria that contribute to Acne Vulgaris.

When is this medication used? Nadifloxacin is occasionally used as a treatment for acne, although it is not available in many countries.  Nadifloxacin is a topical antibiotic that can be used as a treatment for all types of acne vulgaris (Acne Types: 1-4).   Topical Nadifloxacin is generally used in combination with an oral antibiotic or oral retinoid for the treatment of moderate to severe acne (Acne Types: 3-4).

Frequency of Nadifloxacin Resistant P. acnes Bacteria: Rare. (What does this mean?)

Official Name: Nadifloxacin.
Popular Brand Names: Acuatim, Nadixa, Nadixin, Nadiflox and Nadoxin.
Related Medications: Ciprofloxacin, Moxifloxacin, Ofloxacin, Levofloxacin, Norfloxacin, Sparfloxacin, Gatifloxacin.

Important Note: The information provided on this site is intended for informational purposes only and is not intended to diagnose or treat any diseases. The Science of Acne strongly encourages you to consult a qualified medical professional before making any treatment decisions. For the complete disclaimer, click here.

Overall (Composite) Ranking for Nadifloxacin

The COMPOSITE ranking is calculated from a combination of all of the individual rankings for this medication (EFFECTIVENESS, ADVERSE EFFECTS and ANTIBIOTIC SUSCEPTIBILITY).

This ranking is scored on a scale of 1 (WORST) to 5 (BEST).

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Effectiveness Ranking for Nadifloxacin

Nadifloxacin is a topical medication that is occasionally used to treat acne vulgaris.  Nadifloxacin appears to be very effective for treating acne vulgaris.  Nadifloxacin tends to work best for cases of mild to moderate acne (Acne Types: 1-3).    For best results,  is often used in combination with an oral antibiotic, oral retinoid or light-based treatment for the treatment of moderate to severe acne (Acne Types: 3-4).

The EFFECTIVENESS ranking is based on patient reports of how effective this medication was at improving their acne symptoms.

This ranking is scored on a scale of 1 (NOT EFFECTIVE) to 5 (VERY EFFECTIVE).

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Adverse Effects Ranking for Nadifloxacin

Topical Nadifloxacin tends to have minimal side effects, most of which are mild.  Allergic reactions are the most common problem associated with this medication.

The ADVERSE EFFECTS ranking is based on patient reports about the adverse effects and side effects that they experienced with this medication.

This ranking is scored on a scale of 1 (NO SIDE EFFECTS) to 5 (SEVERE SIDE EFFECTS).

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Antibiotic Susceptibility Ranking for Nadifloxacin

The ANTIBIOTIC SUSCEPTIBILITY ranking is based on scientific research reports about the antibiotic sensitivity of Propionibacterium acnes (P. acnes), which is a bacterium that is a primary cause of acne symptoms. Our antibiotic susceptibility data is generated from the combined results of over 50 independent scientific studies. For more information about which antibiotics are most effective against P. acnes bacteria, visit the Antibiotic Susceptibility of Propionibacterium acnes page.

Frequency of Nadifloxacin Resistant P. acnes Bacteria: Rare. (What does this mean?)

This ranking is scored on a scale of 1 (NOT SUSCEPTIBLE) to 5 (VERY SUSCEPTIBLE).

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User Recommendations for Nadifloxacin

The USER RECOMMENDATIONS chart indicates how many reviewers recommended this medication as a treatment for Acne Vulgaris. These recommendations are only from The Science of Acne users. For additional reviews of this medication from outside sources, refer to the section below.

There are four options available for this ranking:

YES (definitely recommended)
MAYBE (conditionally recommended)
NO (not recommended)
DON’T KNOW (no opinion)

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Outside Reviews of Nadifloxacin

The following is a list of links to pages that review or discuss the use of this medication. Note: Some of these reviews are not specific to the use of this medication in the treatment of Acne Vulgaris.

Additional Patient Reviews of Nadifloxacin: Acne.org, MakeupAndBeauty.com.

Nadifloxacin Background

Nadifloxacin is a synthetic, broad-spectrum antibiotic that is a member of the quinolone family of antibiotics.  Like other quinolone family antibiotics, nadifloxacin inhibits the growth of susceptible bacteria by interfering with their ability to synthesize new DNA.  It does this by binding to a bacterial enzyme, DNA Gyrase, which is necessary for accessing the bacteria’s genetic code.  Nadifloxacin inactivates DNA Gyrase, preventing the bacteria from expressing it’s genes and replicating.

Nadifloxacin is active against both Gram-positive and Gram-negative bacteria.  Research indicates that nadifloxacin is very active against most strains of the acne causing bacterium Propionibacterium acnes.  Nadifloxacin appears to efficiently penetrate into the skin tissue, which may make it well suited for the treatment of acne vulgaris.

Nadifloxacin can also change the immune response by decreasing the amount of superoxide ions (free radicals) produced by activated neutrophils (white blood cells).  The release of free radicals into the site of infection can cause inflammation and tissue damage.  Therefore, nadifloxacin may decrease the amount of inflammation and scarring that result from moderate to severe forms of acne vulgaris.

Nadifloxacin is a newer medication and is not yet available in many countries, including the United States.  Although nadifloxacin is structurally similar to other quinolone antibiotics, research suggests that it may be effective against some bacteria that are resistant to other quinolone family antibiotics (eg. ciprofloxacin and levofloxacin).

Additional Names for Nadifloxacin: Acuatim, Activon, Nadibact, Nadicin, Nadiderm, Nadiflo, Nadiflox, Nadifloxacine, Nadifloxacino, Nadifloxacinum, Nadim, Nadiroxisan, Nadiskin, Nadix, Nadim, Nadimax, Nadoxin, Noxin and Zinofloxacin.

Important Note: The information provided on this site is intended for informational purposes only and is not intended to diagnose or treat any diseases. The Science of Acne strongly encourages you to consult a qualified medical professional before making any treatment decisions. For the complete disclaimer, click here.

Cost and Availability of Nadifloxacin

Nadifloxacin is a relatively new medication for the treatment of acne, and it is not yet available in many countries.  Because nadifloxacin is not widely available, it is not a commonly used acne medication.  However, several research studies have indicated that nadifloxacin is one of the most effective topical antibiotics for treating acne vulgaris.

Ciprofloxacin (which is more widely available) is structurally similar to nadifloxacin and may be an effective alternative to topical nadifloxacin.  Topical nadifloxacin may also be combined with other types of treatment (eg. oral antibiotics, topical retinoids or light and laser therapies).

When possible, nadifloxacin should be obtained through consultation of a physician.  Many doctors and dermatologists are not familiar with this medication. Nadifloxacin is not available in many countries. When it is available, topical nadifloxacin tends to be moderately expensive.

Important Note: The information provided above is not intended as a recommendation or endorsement. The Science of Acne encourages you to adhere to all applicable legal regulations in your jurisdiction. Before ordering pharmaceutical medications online, please read our overview: A Guide to Buying Prescription Medications on the Internet.

Related Articles from The Science of Acne

In Depth: Nadifloxacin (Nadixa, Nadiflox) and Acne
Overview: Avoiding Negative Drug Interactions
A Guide to Buying Prescription Medications on the Internet
Overview: Prescription Medications Used in Acne Treatment
In Depth: Antibiotic Susceptibility of Propionibacterium acnes

References and Sources

Books

PDR Staff Writers. 2011. 2011 Physicians’ Desk Reference
Gallagher. 2011. Antibiotics Simplified, Second Edition
Habif. 2009. Clinical Dermatology
Goodheart. 2006. Acne For Dummies
Bartlett. 2012. Johns Hopkins Antibiotics Guide 2012 (Johns Hopkins Medicine)

Online Resources

Nadifloxacin @ Wikipedia
Physician’s Insert for Nadifloxacin

Scientific Research Articles

1. Plewig, et al. 2006. Clinical and bacteriological evaluation of nadifloxacin 1% cream in patients with acne vulgaris: a double-blind, phase III comparison study versus erythromycin 2% cream.
2. Jacobs, et al. 2006. Nadifloxacin: a quinolone for topical treatment of skin infections and potential for systemic use of its active isomer, WCK 771.
3. Marina, et al. 2006. Topical quinolone nadifloxacin (OPC-7251) in bacterial skin disease: clinical evaluation in a multicenter open trial and in vitro antimicrobiological susceptibility testing.
4. Haustein, et al. 1997. The most frequently used topical antibacterial agents in the dermatology practice.
5. Nenoff, et al. 2004. Activity of Nadifloxacin (OPC-7251) and Seven Other Antimicrobial Agents against Aerobic and Anaerobic Gram-Positive Bacteria Isolated from Bacterial Skin Infections.
6. Nenoff, et al. 2006. Acne vulgaris and bacterial skin infections: review of the topical quinolone nadifloxacin.
7. Gübelin, et al. 2006. Antimicrobial susceptibility of strains of Propionibacterium
   acnes isolated from inflammatory acne.
8. Schöfer, et al. 2009. Effectiveness and Tolerance of Topical Nadifloxacin in the Therapy of Acne Vulgaris (grade I-II): Results of a Non-interventional Trial in 555 Patients.
9. Choi, et al. 2010. Clinical Efficacy and Tolerance of 1% Nadifloxacin Cream in the Treatment of Mild to Moderate Acne Vulgaris in South Korea.
10. Tunca, et al. 2010. Topical nadifloxacin 1% cream vs. topical erythromycin 4% gel in the treatment of mild to moderate acne.
11. Kuwahara, et al. 2005. Nadifloxacin, an antiacne quinolone antimicrobial, inhibits the production of proinflammatory cytokines by human peripheral blood mononuclear cells and normal human keratinocytes.
12. Murata, et al. 2006. Nadifloxacin downmodulates antigen-presenting functions of epidermal Langerhans cells and keratinocytes.